Discovery of a personalized therapy for cardiovascular disease

Researchers at the Montreal Heart Institute announced today results showing that patients with cardiovascular disease and the appropriate genetic background benefit greatly from the new medication dalcetrapib, with a reduction of 39% in combined clinical outcomes including heart attacks, strokes, unstable angina, coronary revascularizations and cardiovascular deaths. These patients also benefit from a reduction in the amount of atherosclerosis (thickened walls) in their vessels. The detailed results are published in the prestigious Journal Circulation Cardiovascular Genetics. This discovery may also pave the way for a new era in cardiovascular medicine, with personalized or precision drugs.


The team led by Drs Jean-Claude Tardif and Marie-Pierre Dubé performed the analysis of 5749 patients who received dalcetrapib or placebo and provided DNA in a clinical study. A strong association was discovered between the effects of dalcetrapib and a specific gene called ADCY9 (adenylate cyclase 9) on chromosome 16, particularly for a specific genetic variant (rs1967309). In patients with the genetic profile AA at rs1967309, there was a 39% reduction in the composite cardiovascular endpoint with dalcetrapib compared to placebo. Supporting evidence was also obtained from a second study, which showed that patients with the favourable genetic profile also benefited from a reduction in the thickness of their carotid artery walls with dalcetrapib.

“These results will lead to a genetics-guided clinical study in patients with the appropriate genetic background to allow review by health regulatory agencies and to provide personalized therapy with dalcetrapib. It also offers great hope for precision treatments for patients with cardiovascular diseases and for curbing atherosclerosis, the first cause of mortality in the world” said lead investigator Jean-Claude Tardif MD, director of the Research Center at the Montreal Heart Institute and professor of medicine at the University of Montreal.

The investigators tested multiple genetic markers across the entire genome in a procedure called genome-wide association study. “We used state-of-the-art genetic and statistical techniques to demonstrate that the effect of the patient's genetic profile was only observed in those treated with dalcetrapib and not placebo. We want to provide patients with additional personalized cardiovascular therapies in the years to come, for more efficacious and safer medicines”, commented Marie-Pierre Dubé PhD, director of the Beaulieu-Saucier.

Pharmacogenomics Center at the Montreal Heart Institute and professor of medicine at the University of Montreal.

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Dr. Jean-Claude Tardif is available for interviews.

To read the article:

To consult the Journal of the American heart Association website :

Media Invitation :      Wednesday  January  14 2015 at  10:30 AM

Auditorium Jean Parisien at the Montreal Heart Institute

5000, Bélanger street , Montréal, Québec H1T 1C8

RSVP : Lise Plante 514 376-3330 ext 3898

Dr Jean-Claude Tardif will present the study highlights.

About the Montreal Heart Institute

Founded in 1954 by Dr. Paul David, the Montreal Heart Institute constantly aims for the highest standards of excellence in the cardiovascular field through its leadership in clinical and basic research, ultra-specialized care, professional training and prevention. It is part of the broad network of health excellence made up of Université de Montréal and its affiliated institutions.

About the Montreal Heart Institute Foundation

The mission of the Montreal Heart Institute Foundation is to raise and administer funds to support the Institute's priority and innovative projects and help its fight against cardiovascular disease, the number-one cause of death worldwide. Since its creation in 1977, the Foundation has donated almost $200 million to the Montreal Heart Institute.


Lise Plante MBA

Communications and Marketing Director

Montreal Heart Institute Foundation

Phone: 514-376-3330, extension 3898 | | @ICMtl