Immune system mechanisms: The work of Dr. Jean-Sébastien Delisle is recognized

Dendritic cells.

Dendritic cells.

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The Journal of Immunology has ranked the most recent research of Professor Delisle among the top 10% of its best scientific articles.

The recent work of Dr. Jean-Sébastien Delisle of the Maisonneuve-Rosemont Hospital Research Center (CIUSSS-EMTL) affiliated with the University of Montreal, which uncovers novel immune system mechanisms, has been recognized by the highly respected Journal of Immunology. Indeed, the official journal of the American Association of Immunologists has ranked Dr. Delisle’s article published in its November 15 issue among the top 10% of its best scientific articles.

An important step towards understanding immunity

Professor Jean-Sébastien Delisle.

An The research of Dr. Delisle and his team has identified the unexpected role of Neuropilin-1, a membrane receptor, and the phenomenon of dendritic cell maturation, which is an essential link in the immune response to infection and disease. The scope of this work is considerable because it involves identifying a new target for optimizing immune responses for a large number of diseases.

“Dr. Delise’s discovery is timely and will help improve the way the immune system is used to treat cancer,” said Dr. Denis-Claude Roy, scientific director of the Centre de recherche Hôpital Maisonneuve-Rosemont. “

“By targeting this mechanism, we can eventually consider the possibility of improving the responses in conditions unfavourable to the immune system, especially with respect to many cancers,” added Dr. Delisle.

It is not the first time Dr. Delisle’s research has been recognized. Recently, his Phase 1 clinical study EBV-TCL-01, using laboratory-manipulated cells as an innovative treatment for Epstein-Barr virus-associated lymphomas, received approval from Health Canada, a first for the country.

About the CIUSSS du Centre-Sud-de-l'Île-de-Montréal

The Centre intégré universitaire de santé et de services sociaux du Centre-Sud-de-l'Île-de-Montréal (CIUSSS-CSMTL) was created on April 1, 2015, from the merger of 10 health and social services institutions on the Island of Montreal. It provides services to a population of nearly 300,000 Montrealers who live on the southern part of the island in the boroughs of Ville-Marie, Verdun, Le Sud-Ouest, Le Plateau-Mont-Royal and part of Rosemont–La Petite-Patrie. It also has a regional responsibility for such services as rehabilitation, youth services, public health and emergency measures. With four institutes and two university-affiliated centres in the health and social services sectors, the CIUSSS-CSMTL fulfills a significant academic mission.

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